This new decade of 20s is likely to witness a significant intersection between three critical topics discussed in the 21st century: 1) digital, 2) human capital and 3) leadership. Employees, managers and leaders across the world will seek answers to questions such as: How do we transform traditional organizations in the face of the digital onslaught? How will we sustain agility in organizations to deal with digital demands? How do we build cross-border capabilities in an increasingly narrowing world order?  What new skills and cognitive versatility will leaders need to cope with the new realities unleashed due to the digital revolution? How can we build inclusive work places and handle biases-will AI /ML help? How do we understand human needs beyond the current confines of money and material comfort. The thoughtful and topical essays written by well-known faculty- affiliated with the Human Capital and Leadership Initiative (HC&LI) at ISB provide emerging perspectives on some of these pressing questions. -These nuanced, lucid write-ups are aimed at stimulating practitioners and enriching their understanding on bravely taking on the challenging new decade of 2020s.