Synopsis The first real drug to treat high blood pressure was given to the rest of the world by India's indigenous system of medicine, the Ayurveda wherein roots of the plant Rauwolfia seprentina had been used for various ailment. Present study deals with an investigation on the hypotensive response of Terminalia arjuna. Wright and Arnott, a medicinal plant from the Indian System of Medicine I.e. Ayurveda. Arjuna extract had produced a significant fall of blood pressure along with decrease in heart rate, and these actions were mediated through both central and peripheral mechanism. T. around is not a cardiontonic but is an effective depressant. Like digitals, it is also a good diuretic.