Bhavaprakasa is a land in the history of Ayurvedic Medicine. It is one the three famous book on Ayurveda, together known as laghutrayi. The author Bhavmisra wrote this treatise in 16th century A.D. This was one of the best compilations of medical knowledge prevalent in medieval period on the use medicinal plants and treatment of various diseases. This volume the first part of purvardha contains a lot of information on the basic concepts and five purificatory procedures (pancakarma) along with Nighantu (lexicon). The Nighantu part clarifies many controversies on medicinal plants and exemplified many exotic plants species making it an esteemed treaties for academicians of Ayurveda and Botany. Bhavamisra also added some new formulations and treatment methods, dwindling its importance. The present commentary on the text is the first of it kind in English. A study of the plant drugs in terms of nomenclature botanical identification, morphology and habitant is done elaborately. Updated phytochemistry and important therapeutic uses are included under the description of each plant. Latest scientific names including the varieties of plants are mentioned. This commentary will be widely welcomed by students and practitioners of modern medicine and by scientists interested interested in the vast extent and rich content of the pharmacopoeia of Ayurvedic science. A legible translation of the original text helps persons to understand the charm of Ayurveda in the middle ages.