Synopsis The Eastern Ghats, one of the nine floristic zones in India, are located between 11o30’ and 22o N latitude and 76o 50’ and 86o 30’E longitude in a North-East to South-West strike. The Eastern Ghats are spread over three states of India, namely Orissa, Andhra Pradesh and Tamil Nadu. It covers an area of about 75, 000 sq. km. with an average width of 200 km. in the north and 100 km. in the south. They extendover a length of 1750 km. between the rivers Mahanadi and Vaigainal along East Coast. Topography and general features, present work and vegetation types are given in the beginning. The next part includes systematic enumeration where the families have been arranged according to Bentham and Hooker’s system with incorporation of recent changes. Under each family key to the genera, followed by the genus with its authority, keys to the species and species enumeration is given. The genera under the family and species under the genus are arranged in alphabetical sequence. Keys are of the indented type. The enumeration of species includes citation according to ICBN, basionym and synonym if any, description, distribution in the Eastern Ghats, flowering and fruiting period, vernacular names, specimens examined and distribution in India and world. Bibliography, index to families, genera and species are given at the end.