Synopsis This volume in based on empirical study carried out to understand the determinants of truckers vulnerability to HIV and develop a perspective to do social work practice with them. The volume is divided in eight-chapters. Chapter one describes the HIV infection as a public health challenge. Chapter two explore the epidemiology of the infection at global, regional level. It provides insights into the epidemic in India and Delhi and specially on high risk groups. Chapter three is based on review of existing literature which including books, studies and other material available. Chapter four describes the purpose of the study, objectives, methodology etc. Chapter five explores and analyses the social environmental of truckers. Chapter six discusses the profile of respondents, their working undertones and life style. Chapter seven highlight the determinds of vulnerability and analyze the vulnerably of truckers. Chapter eight discuss the perspective of social work practice with trucker in order to emotionate their conditions which many lead to reduction of HIV. This book is provides a holistic approach of looking at the problem of HIV in the country. It provides a frame work to overcome the problem. With its unique bleu of a imitative and quantitative informative and its emphasis on the need to develop practical intervention programme based on a frank understanding of behaviors, attitudes and environment, this book will be immense use to a made audience. This includes public health professionals, social workers, NGOs as also researchers, policy makers and educators involved with HIV/AIDS.