This book is the basic book indented as a course supplement to students of B.A.M.S, M.D, Medical officers and Practitioners of Ayurveda. This text book describes all the vital topics related to Vikruti Vigyan and Roganidana and Kayachikitsa paper-1. This text book covers both clinical and Laboratory diagnosis of the disease. It is the book written in English which includes new chapters like Sushurtokta Dwadasha Pariksha, Concept of Agni, Astoumahagada, Padachtustaya, Janapadodwamsa, Doshavaha Srotas and Ojovaha Srotas. Diagnosis of the diseases is completely depends upon the proper history talking, clinical examination and ancillary investigations. All these aspects covered in this text book. It is the classical book on Ayurvedic diagnostics.