The concept of Ama is deep-rooted in all the segments of Ayurveda like Nidana (pathology), Kaya Chikitsa (treatment) and Salya Chikitsa (Surgery) etc., and in fact, it (ama) is considered as one of the Vital Vyadhi Ghataka (VVG) responsible for the initiation of the disease process in the body, hence called as Amaya in Ayurveda, which is a well known synonym for Vyadhi (disease). This it self illustrates the potentiality of ama. It's role in certain disease entities is as significant as that of dosa, amavata and visachikitsa are the classical examples, hence it had been termed as 'ama dosa' in these contexts. Similarly, because of its rapidity and toxic like action on the human system i.e. 'asukari svabhava', it has been described as 'ama visa' in some other instances. All these facets of ama needs a close and scientific scrutiny, so as to understand its pathogenic nature in a proper perspective for better clinical success