Dhanwantri Nighantu, when it was composed, is still to be traced. However, it can be said with certainty that Dhanwantri Nighantu is principle text of Ayurveda as far as description of medicinal plants is concerned. The plant have been arranged in distinct seven groups. Medicinal plants mentioned in seven groups have been discussed with respect to synonyms, Ayurvedic pharmacology and action on three biological homours, actions and therapeutics. A complete chapter has been devoted to study of metals. While carrying out English translation of the ancient text, include botanical names and natural order along with principle Sanskrit name of the medicinal plant. Same is applicable to description of metals and drugs of animal origin. Modern equivalent of disease pattern described in Ayurveda have been mentioned for reader's benefit. Hope this work will be useful for Ayurvedic practitioners and researchers. This book in no way can replace other scholarly publications on Dhanwantri Nighantu but will be useful addition to old literature.